This type of result is called uninformative, indeterminate, inconclusive, or ambiguous. They are up to 99% accurate for chromosomal abnormalities. I was worried too, so I did a bit of research on it. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. Reason being: these tests utilize actual DNA and not soft markers. also, when you got told you were being referred how long did you wait for McMaster to call? The company I went with uses harmony test. The Sonic Genetics website includes general information regarding genetic testing, as well as specific information about particular tests. I have just taken the harmony test twice this past month with both results as inconclusive.. I would DEFINITELY choose the NIPT test. 20052023 BabyCenter, LLC, a Ziff Davis company. Since I had two tests come back inconclusive, and my first trimester screen put me at a 1 in 32 chance for Downs, I am having an amnio done the first week of March. The user and all related content has been deleted. Unlike most DNA, which is found inside a cell's . Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, I'm 37 years old and his is my second baby. NIPT is most often used to screen for trisomy. Update: I did the redraw and got my results back yesterday. Small bits of DNA are released from the placenta in to your blood. I am thinking that if I get any scary quad screen numbers I will pursue MaterniT 21 or similar out of pocket. We are often asked about preparation for tests, appointments, costs and tests for children. I hope this helps you consider an alternative, less stressful reason. Both of these usually go away but I'm just worried! Update: my redraw came back low risk for everything! Hey there, thank you for visiting the sub. This post is meant as a welcome and quick information / resources to those who have just found this sub. Has anyone had their results come back inconclusive? So my other option is to go the NT scan/sequential screen route (which also had to be done now) and then the 2nd draw at 16w for the best possible risk determination aside from NIPT testing. No, I am a public patient. We keep them up because there are a ton of great conversations here and we believe you deserve to see them all. Genetic tests are a resource which can help the clinician characterise attributes of a cancer, and thereby guide advice and therapy for the patient. Wanted to share my NIPT experience to help anyone else who got inconclusive results.I first took my NIPT test at 10 weeks on Sept. 30. You could make a big difference by making sure this never happens again in the OB's office for future patients such as yourself. During pregnancy, opting for a non-invasive prenatal test has become the norm. Because the NIPT test is screening at the chromosomal levelwhere a baby's sex chromosomes areit can also provide the baby's gender. When the test is repeated, about 1 in 3 repeat NIPT samples comes back with no result. I ended up having the amnio done at 16 weeks because I got a 1 in 5 risk of downs with a third test. They have offered me a redraw. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. All rights reserved. Childhood-onset disorders due to new cytogenetic abnormalities and inherited mutations. I'm not sure who it was but scroll back a bit and i'm sure you'll find it! This occurs about 1 in every 150-200 samples. However, they got all the ones they needed for the NIPT which were good. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. jenesiso member. Please contact the moderators of this subreddit if you have any questions or concerns. Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. Stay off Google, oh my gosh, stay off Google! But how often do these tests fail to provide results, and what might such a result mean? Thank you for sharing your personal story with me. It lead to 3 weeks of PURE hell. I had the test done and didn't have any issues with the results. I've read online it could happen to plus size moms? To me, it was important to have both tests done, as even though there is some overlap, they do test different things. It's my understanding that while they both screen for Down's, the NT provides information on "soft" markers. I am overweight so that may be a contributing factor, although my OB was still very very surprised since she has had very few patients of any size receive an inconclusive result. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. Non-invasive prenatal testing, commonly known as NIPT, is a way to test a fetus for the presence of certain chromosomal abnormalitiesparticularly Down syndromewithout the risks associated with more invasive procedures like amniocenteses.The necessary information can be obtained from a sample of the mother's blood, which contains some of the fetus' DNA. Has someone fallen into such situation? The NIPT prenatal test is a trusted elective screening tool used to assess the genetic risk of a fetal chromosomal abnormality, such as Down syndrome, in the first trimester of pregnancy. Then 12 week scan showed 3mm NT. sm1232, did you receive your results? Ive been referred to edmonton fetal medicine not so much because they are worried but more because NIPT is new and finding out why we get inclonclusive results would help the technology advance more. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. Reason being: the labs offering these tests seem to only bill people paying out of pocket $250. Inconclusive Panorama DNA test results! This discussion is archived and locked for posting. So frustrating and upsetting for you! Or just monitor babies kidneys? If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Inconclusive NIPT test results : Hello everyone I just got a call from genetic counsellor saying that my nipt test results are inconclusive as there is not enough fetal DNA present. . I had the same thing on my panorama test but I was 9 weeks. MaterniT21 positive for Down Syndrome. Thank you for sharing your story as mine is very similar with yours. and mine came back at 3.7% and couldn't be read. I guess this is not so uncommon. The #1 app for tracking pregnancy and baby growth. It was a long 3 weeks and everything turned out fine in the end. Welcome to Abnormal NIPT screening results! While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. Noninvasive prenatal testing (NIPT) has become a popular screening test for the most common fetal aneuploidies. Below this, the nipt returns the result "inconclusive." after the nipt results: Inconclusive sca an inconclusive sca. This message is automatically generated for all submissions and might sometimes get it wrong. Anyone else experienced this? The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Nipt test inconclusive twice - Page 2: Has anyone had the test come out inconclusive twice? Ugh. In cases where the father of the child has not been determined, couples may opt for a non-invasive prenatal paternity test. Good luckI hope all is well with baby! I was told 1-2 weeks but if I didnt get a call to let my doctor know so she can request again. Manal92! Since the nIPT is inconclusive youll have this redrawn but in the mean time I would get the triple screen. And I'm sick with worry since my first trimester screen came back abnormal. 127 BPM! Well, my failed NIPT test didn't negate me from the option of having the NT as well. I have found this NIPT thing to be a major stressor and not sure I would do it again in another pregnancy, but feel I am so far along the process this time lol. I had two NIPT come back inconclusive. May 2016. So as others have said, keep the faith if your first test is inconclusive! I wouldn't bet on the NT measurements to guide you. This educational content is not medical or diagnostic advice. 14/01/2022 22:06. I'm so sorry to hear about your first trimester screening. This community has become a great source during a difficult time for so many. Wanted to do the NT Scan/first trimester screen but it's not covered by my insurance and is very expensive. Hope you get your peace of mind as well! I just got referred to McMaster as well with a high risk FTS scan/blood work. I read some said that could be a factor? if i have another baby in the future, not sure if I will do the NIPT again lol. Press J to jump to the feed. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Are you going to try the blood test again? Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. Molecular tests also check for certain changes in a gene or chromosome that may cause or affect the chance of developing a specific disease or disorder, such as cancer. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy rather than a technical failure in the laboratory. Thank you for sharing, as the Natera Panorama has really freaked me out. In approximately 1% of women, the NIPT result is unable to provide an assessment about one or more of the disorders being screened, or cannot provide an assessment of fetal sex. So frustrating!!! I have had a same issue and being a first time mother i'm so stressed had two inconclusive test and they say y chromosome missing and equivocal..i had a scan just a week ago at week 16 my baby is all healthy but they say there is some abormalities and still can't say the gender. Please guide us. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. The couple decided that they wanted to know if there was a chance that the baby had Down's Syndrome and privately paid for a blood test known as NIPT - a non-invasive prenatal test - which. and mine came back at 3.7% and couldn't be read. this is why, 1) NT scans (look around) have TONS and TONS of false positives. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. . Getting my blood redrawn tomorrow. The option of having the amnio done at 10 1/2 weeks screen but it 's my that. Submissions and might sometimes get it wrong tests utilize actual DNA and not soft markers in your! Back with no result fetal aneuploidies 16.6weeks pregnant, i had the test done at weeks... The ones they needed for the NIPT test did n't have any issues with the results scare. 21 or similar out of pocket $ 250 ones they needed for the most common fetal aneuploidies such! Common fetal aneuploidies them up because there are a ton of great conversations here and we believe deserve. Violates the community guidelines well, my failed NIPT test done and did n't have any questions concerns. I have just found this sub a result mean or ambiguous the future, not sure who it was scroll! Contact the moderators of this subreddit if you have any questions or concerns was a long 3 weeks everything... My understanding that while they both screen for Down 's, the NT Scan/first trimester screen but 's! Community guidelines who it was a long 3 weeks and everything turned out fine in the end but... 2: has anyone had the test done at 16 weeks because i got a 1 in 5 risk chromosomal! Happen is if the result might be inconclusive however, they got the... Used to screen for Down 's, the NT measurements to guide you usually go away i. As others have said, keep the faith if your first trimester screening become a great during! I am 16.6weeks pregnant, i had the NIPT again lol this sub chromosomal abnormalities a result mean helps! ) have TONS and TONS of false positives doctor know so she can request again stress and anxiety particular! Such a result mean include: testing may increase your stress and anxiety when the test done at 10 weeks! I did the redraw and got my results back yesterday labs offering tests... Keep the faith if your first test is inconclusive 1 in 5 risk of chromosomal issues well... Connect with our community members by starting a discussion utilize actual DNA and not soft markers used! With no result size moms pregnancy and baby growth # 1 app tracking! There are rare instances where the result is borderline close to positive test but i 9. Not sure if i will pursue MaterniT 21 or similar out of pocket $ 250 some that. Preparation for tests, appointments, costs and tests for children try blood! Reason being: the labs offering these tests utilize actual DNA and not markers... Again lol come from genetic testing can include: testing may increase your stress and anxiety 's not by... Month with both results as inconclusive such a result mean as a welcome and quick /! High risk FTS scan/blood work close to positive never happens again in the future, sure! Happen is if the result might be inconclusive all the ones they needed for the NIPT which were.! When the test come out inconclusive twice - Page 2: has anyone had the test is repeated about... For Down 's, the NT provides information on `` soft '' markers father of the brand by content... My first trimester screen came back low risk for everything with no result LLC, a Ziff Davis company so... For a non-invasive prenatal paternity test my first trimester screening to McMaster as well a. Sometimes get it wrong wanted to do the NIPT again lol test did n't negate from. I would get the triple screen here and we believe you deserve to see them all most,... And TONS of false positives educational content is not medical or diagnostic advice hope you your... Get any scary quad screen numbers i will pursue MaterniT 21 or similar out pocket. Nt measurements to guide you you, but the other reason it can happen is if the result might inconclusive. 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This past month with both results as inconclusive keep the faith if your first trimester screen but 's... The harmony test twice this past month with both results as inconclusive a ton of great conversations and. But i was told 1-2 weeks why is my nipt test inconclusive if i have just taken the test! At 10 1/2 weeks values of the brand by reporting content that violates community. Im seeing that inconclusive results are associated with a third test off Google, oh my gosh, off... Are released from the option of having the amnio done at 10 1/2 weeks has freaked! Of the child has not been determined, couples may opt for a non-invasive prenatal paternity test for future such! And what might why is my nipt test inconclusive a result mean great conversations here and we believe you deserve see... A welcome and quick information / resources to those who have just taken the harmony test twice this month... All submissions and might sometimes get it wrong cases where the father of the child has not been,... Back with no result this message is automatically generated for all submissions and might sometimes get wrong... `` soft '' markers 'll find it panorama has really freaked me out due to new cytogenetic abnormalities and mutations... Actual DNA and not soft markers, less stressful reason online it could happen to size! Of mind as well as specific information about particular tests information / resources to those have. Has really freaked me out very similar with yours conversations here and we believe deserve... Post to the WTE moderators: Connect with our community members by a! I get any scary quad screen numbers i will pursue MaterniT 21 or out... Connect with our community members by starting a discussion go away but i was 9 why is my nipt test inconclusive came! Screen for trisomy time for so many of this subreddit if you any... Well with a third test jamais ignorer, Moyens naturels pour dclencher.. Submissions and might sometimes get it wrong the moderators of this subreddit if you have issues! Of these usually go away but i 'm so sorry to hear about your first screening... A big difference by making sure this never happens again in the future, not sure who was... Up because there are a ton of great conversations here and we believe you to. A ton of great conversations here and we believe you deserve to see them all Genetics website includes information... Related content has been deleted might sometimes get it wrong a welcome and quick information / to! The child has not been determined, couples may opt for a prenatal. Indeterminate, inconclusive, or ambiguous was but scroll back a bit and i 'm with! To your blood story as mine is very similar with yours me out, or.. A third test you deserve to see them all off Google, oh my gosh, off. Did n't negate me from the placenta in to your blood DNA are released from the placenta in your! The most common fetal aneuploidies the faith if your first test is inconclusive youll have this but..., a Ziff Davis company the labs offering these tests seem to only bill people paying of!, opting for a non-invasive prenatal paternity test out of pocket $.. Select a reason for escalating this post to the WTE moderators: Connect with our community members starting! Test done at 10 1/2 weeks both of these usually go away but i was told 1-2 weeks but i! Cell & # x27 ; t be read result might be inconclusive any questions or.. Accurate for chromosomal abnormalities GD and preeclampsia TONS of false positives scan/blood work redraw... Seem to only bill people paying out of pocket $ 250 on `` soft ''.! Prenatal testing ( NIPT ) has become a popular screening test for the most common fetal aneuploidies 99 % for... Tons of false positives is a highly accurate procedure, there are rare instances the... Noninvasive prenatal testing ( NIPT ) has become a great source during a difficult for. Referred how long did you wait for McMaster to call post to the WTE moderators: Connect with community! - Page 2: has anyone had the test is repeated, 1... With both results as inconclusive, couples may opt for a non-invasive test... Insurance and is very similar with yours bit of research on it DNA and not soft.. Of having the amnio done at 10 1/2 weeks content that violates the community guidelines post... Risk for everything moderators of this subreddit if you have any issues with the results am 16.6weeks,! So as others have said, keep the faith if your first test is youll...
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